Proper management of metabolic waste is essential for maintaining optimal health, particularly for individuals with chronic kidney disease (CKD) and urea cycle disorders (UCD). CKD affects a significant number of Americans each year, and monitoring these conditions at home is challenging, leading to suboptimal patient care, increased morbidity, and fewer clinician touchpoints throughout the patient journey. Similarly, UCDs, rare diseases hindering the conversion of ammonia into urea, require meticulous monitoring to prevent hyperammonemia. At Enhance Diagnostics, we have developed an at-home breath test for ammonia, offering a convenient solution for both CKD and UCD patients. 

Our platform demonstrates a strong correlation between breath ammonia and blood urea nitrogen (BUN) in CKD patients, as well as a direct correlation to blood ammonia levels in those with UCDs. This innovation allows for quantitative, real-time patient monitoring at home, eliminating the need for frequent in-person visits and providing valuable insights without the necessity of a blood test. For CKD patients, our device promises low-cost, non-invasive, and private testing, addressing the challenges associated with at-home monitoring. Similarly, individuals with UCDs can benefit from real-time, at-home testing, offering insights into ammonia levels without the need for invasive blood tests, thereby providing substantial cost savings for the patients.